Figure 5 | Scientific Reports

Figure 5

From: Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus

Figure 5

PSTi8 modulate insulin signaling. Western blot analysis of (a–c) phosphorylation of IRS-1 (p-S307IRS-1), (d–f) phosphorylation of Akt (p-T308AKT), (g–i) phosphorylation of Srebp-1c (p-S372SREBP1c) and (j–l) phosphorylation of FoxO1 (p-S256FoxO1) in liver tissues of db/db, HFD, HFrD mice and PSTi8 treated db/db, HFD, HFrD mice. α, control vs db/db, HFD, HFrD and β, db/db vs db/db + PSTi8, HFD vs HFD + PSTi8, HFrD vs HFrD + PSTi8. *P < 0.05; **P < 0.01; ***P < 0.001. Error bar indicate mean ± s.e.m.

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