Figure 7 | Scientific Reports

Figure 7

From: Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus

Figure 7The alternative text for this image may have been generated using AI.

Mechanism of action of PSTi8 towards glucose and energy homeostasis. PSTi8 pre-occupy the GRP78 receptor where PST binds. PST regulation of glucose homeostasis in different tissues which is inhibited by PSTi8 in metabolic syndrome and type-2 diabetes. Schematic diagram showing the inhibitory effect of PSTi8 on PST at PST receptors in the liver. GPCR, G protein-coupled receptor; PKC, protein kinase c; PI-3K, phosphatidylinositol 3-kinase; pFoxO1, phosphorylated FoxO1; Srebp-1c, Sterol regulatory element-binding protein 1c; Akt, protein kinase B; PIP3, Phosphatidylinositol (3,4,5)-trisphosphate; IRS1, Insulin receptor substrate 1; GTP, Guanosine triphosphate; cGMP, Cyclic guanosine monophosphate; NOS, Nitric oxide synthase.

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