Figure 5 | Scientific Reports

Figure 5

From: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine

Figure 5

Overlay of spDnmt2 cross-links to tRNAAsp with lysine and arginine residues known to be important for Dnmt2 catalytic activity in human. spDnmt2 and hsDnmt2 were superimposed and depicted as cartoon. spDnmt2 residues cross-linked to tRNAAsp are depicted as green spheres, hsDnmt2 residues for which single mutation to alanine resulted in <25% activity compared to wildtype are shown as red spheres.

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