Figure 9 | Scientific Reports

Figure 9

From: Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta)

Figure 9

Multiple alignments of Cyclin D protein among humans, monkeys, bovines, pigs and turtles. The amino acid sequences were obtained from the UCSC Genome Bioinformatics database (http://www.ucsc.edu). The conserved amino acids are highlighted with black boxes. The functional motif of LXCXE (which is important for the binding with pRB), the Cyclin kinase box, and the LLXXXL motif (which is important for the binding with steroid receptor co-activators) are underlined.

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