Table 3 Association of genotypes with mutational pattern in gyrA (108 FQ mono-resistant and 17 XDR-TB) and rrs gene regions (2 AG/CP mono-resistant and 17 XDR-TB isolates) detected by Genotype MTBDRsl assay on 125 culture isolates.

From: Association of gyrA and rrs gene mutations detected by MTBDRsl V1 on Mycobacterium tuberculosis strains of diverse genetic background from India

Codon mutation (gyrA)

Total no. of isolates (%)

Genotype (%)

Beijing

CAS

EAI

H

Manu

T

Ural

Unique

X

ΔWT3-D94G

51 (40.8)

23 (45.1)

14 (27.4)

—

1 (1.9)

1 (1.9)

3 (5.8)

—

4 (7.8)

5 (9.8)

ΔWT3-D94A

6 (4.8)

4 (66.7)

1 (16.7)

—

—

—

—

—

1 (16.6)

—

ΔWT3-D94N/Y

6 (4.8)

6 (100)

—

—

—

—

—

—

—

—

ΔWT3-D94H

5 (4)

3 (60)

2 (40)

—

—

—

—

—

—

—

ΔWT3

3 (2.4)

2 (66.7)

1 (33.3)

—

—

—

—

—

—

—

ΔWT2-A90V

31 (24.8)

10 (32.2)

8 (25.8)

3 (9.7)

—

3 (9.7)

2(6.4)

2 (6.4)

2 (6.4)

1(3.2)

ΔWT2-S91P

1 (0.8)

1 (100)

—

—

—

—

—

—

—

—

+WT-A90V

3 (2.4)

2 (66.7)

—

—

—

—

1(33.3)

—

—

—

+WT-D94G

2 (1.6)

—

2 (100)

—

—

—

—

—

—

—

+WT-D94H

2 (1.6)

2 (100)

—

—

—

—

—

—

—

—

+WT-D94A

1 (0.8)

—

—

—

—

—

1 (100)

—

—

—

ΔWT3-D94G- D94H

2 (1.6)

—

—

—

—

—

—

—

2 (100)

—

A90V, D94A

2 (1.6)

1 (50)

—

1 (50)

—

—

—

—

—

—

+WT-A90V- D94G

7 (5.6)

2 (28.6)

3 (42.8)

—

—

—

—

—

2 (28.5)

—

+WT-A90V-D94A

1 (0.8)

—

1 (100)

—

—

—

—

—

—

—

ΔWT3-D94A- D94G

1 (0.8)

—

—

—

—

—

1 (100)

—

—

—

ΔWT3-D94N/Y- D94G-D94H

1 (0.8)

—

1 (100)

—

—

—

—

—

—

—

Total:

125 (34.8)

56 (44.8)

33 (26.4)

4 (3.2)

1 (0.8)

4 (3.2)

8(6.4)

2 (1.6)

11 (8.8)

6 (4.8)

Codon Mutation ( rrs )

ΔWT1-A1401G

11 (57.9)

6 (54.5)

2 (18.2)

1 (9.1)

—

—

1 (9.1)

—

1 (9.1)

—

ΔWT1-G1484T

1 (5.3)

—

—

—

—

—

—

—

—

1 (100)

ΔWT1-C1402T

1 (5.3)

1 (100)

        

+WT-A1401G

6 (31.6)

3 (50)

2 (33.3)

—

—

—

—

1 (16.7)

—

—

Total:

19 (5.2)

10 (52.6)

4 (21.1)

1 (5.3)

—

—

1 (5.3)

1 (5.3)

1(5.3)

1 (5.3)

  1. ΔWT- Deletion of wild type band. +WT- Presence of wild type band.
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