Figure 2 | Scientific Reports

Figure 2

From: Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time

Figure 2

The effects of level of exposure to P. falciparum and age on affinity. (a) Comparison of antibody affinity to EBA175 and PfRh2 between individuals that encountered P. falciparum more frequently (median parasitemia >0 for the study period), high exposure, and individuals with low exposure. For high exposure n = 129, for low exposure n = 159; p values were calculated using Mann Whitney test (p < 0.001 = ***). Bars represent standard error of the mean. (b) Antibody affinity to EBA175 and PfRh2 for age groups 5–15 and >15 years. Statistical significance was determined by Mann Whitney test (p < 0.001 = ***), bar represent standard error of the mean. (c) Antibody affinity profile of participant NR38, 6 years old, who had the highest antibody affinity of all 288 samples on day 30. The right axis has been reversed.

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