Table 2 Results obtained for the described UPLC-MS/MS & HPLC-UV methods for determination of OG in bulk and tablets.

From: Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent

Item

UPLC-MS/MS

HPLC-UV

Regression Eq.

Y = 14.561 × +310.35

Y = 1070.3 × +30.4

Correlation Co.

0.9999

0.9997

*LOD

6.67 ng/mL

0.67 µg/mL

*LOQ

20 ng/mL

2 µg/mL

Range

20–2700 ng/mL

2–10 µg/mL

Accuracy (*R%)

99.88% ± 0.7

—

Precision (*% RSD)

0.71%

—

Tablets (Marizev®)

Recovery = 98.08%

—

  1. *Where LOD is the limit of detection, LOQ is the limit of quantification, R% is the mean recovery percent and % RSD is the percent relative standard deviation.
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