Figure 1 | Scientific Reports

Figure 1

From: Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin

Figure 1

Sort1 deficiency reduced body and WAT weight in female Ldlr−/− mice. (a) Body weight in grams (g), (b) body weight gain, and (c) WAT weight ratio for Ldlr−/−Sort1+/+ and Ldlr−/−Sort1−/− mice after 15 weeks (15w) on normal chow (NC) or high-fat/cholesterol diet (HF/HC); (n = 5–10 mice/group). (d) Confirmation of Sortilin protein deficiency in 15-week HF/HC-diet fed female Sort1−/− mice WAT and brown adipose tissue (BAT); (n = 5 mice/group). GAPDH loading controls were run on the same blot, and the membrane was cut prior to incubating with primary antibody. Full-length blots are presented in Supplemental Fig. S4a and b. *P < 0.05, **P < 0.01, ***P < 0.001 versus sex and diet matched Ldlr−/−Sort1+/+ mice, analyzed by t-test; values are presented as mean ± SEM.

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