Figure 5
Sort1 deficiency decreased LXR-related transcription in female Ldlr−/− mice on a HF/HC diet. (a) Heat maps of LXR-related, sterol synthesis-related, and sterol trafficking-related genes mRNA levels in WAT, BAT, and jejunum tissue of female mice fed a HF/HC diet for 15 weeks (P value shown for each gene; data also presented as bar graphs in Supplemental Fig. S3); (n = 5–6 mice/group). (b) Klf4 mRNA levels in WAT, BAT, and jejunum of female mice on a HF/HC diet for 15 weeks; (n = 6 mice/group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. Ldlr−/−Sort1+/+, analyzed by t-test; values are presented as mean ± SEM.
