Table 2 Hematological and biochemical parameters in arterial blood from rats in the Control, CCl4-1xWk and CCl4-2xWk groups.

From: Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility

 

Control (n = 11)

CCl4-1xWk (n = 10)#

CCl4-2xWk (n = 10)#

Blood cell count

Red blood cells (x10 6 /μl)

7.7 [7.2, 8.0]

7.6 [7.5, 7.8]

6.9 [6.4, 7.5]

Hemoglobin (g/dl)

14.0 [13.6, 14.6]

13.6 [13.3, 14.2]

13.2 [12.5, 13.6]*

Hematocrit (%)

40.2 [38.7, 41.7]

39.8 [38.7, 40.8]

38.8 [38.1, 40.6]

MCV (fl)

54.3 [51.2, 54.9]

52.3 [50.6, 54.4]

56.7 [54.1, 61.0]θ

White blood cells (x10 3 /μl)

1.5 [0.9, 3.7]

1.1 [0.9, 2.2]

7.2 [2.6, 15.8]*,θ

Platelets (x10 3 /μl)

886 [859, 1011]

866 [798, 955]

525 [363, 706]**,θ

Coagulation

Prothrombin time (s)

11.5 [10.0, 12.6]

11.7 [11.2, 11.9]

15.1 [13.3, 17.0]**,θθ

INR

1.05 [0.91, 1.16]

1.07 [1.05, 1.10]

1.39 [1.23, 1.56]**,θθ

Fibrinogen (mg/dl)

236 [194, 247]

234 [212, 253]

144 [97, 209]*,θθ

Blood biochemistry

Glucose (mg/dl)

197 [166, 259]

163 [160, 201]

122 [101, 168]**

ALT (U/l)

27 [25, 41]

41 [28, 61]

76 [54, 89] ****, θθ

AST (U/l)

54 [47, 63]

67 [46, 95]

210 [170, 291]***,θθ

Total Bilirubin (mg/dl)

0.10 [0.03, 0.10]

0.10 [0.10, 0.10]

0.45 [0.18, 0.90]**,θ

AP (U/l)

66 [60, 75]

125 [101, 147]**

236 [127, 297]**

Albumin (g/dl)

3.5 [3.2, 3.7]

3.2 [3.2, 3.5]

2.6 [2.1, 2.8]****,θθθθ

Total Proteins (g/dl)

5.3 [5.2, 5.5]

5.3 [5.0, 5.5]

4.5 [4.2, 4.6]**,θθ

LDH (U/l)

138 [110, 214]

155 [92, 210]

207 [198, 390]θ

Creatinine (mg/dl)

0.34 [0.26, 0.36]

0.28 [0.24, 0.34]

0.20 [0.20, 0.24]*

Urea (mg/dl)

28 [22, 32]

27 [22, 32]

20 [18, 25]

Sodium (mmol/l)

137 [136, 140]

139 [138, 142]

139 [139, 142]

Potasium (mmol/l)

4.9 [4.6, 5.8]

5.3 [5.0, 5.5]

5.6 [5.1, 6.2]

Arterial blood gases

pH

7.39 [7.33, 7.47]

7.44 [7.42, 7.48]

7.38 [7.33, 7,43]

pCO 2 (mmHg)

46 [40, 51]

40 [36, 42]

51 [46, 57]θθ

pO 2 (mmHg)

441 [341, 478]

455 [439, 478]

409 [336, 435]

HCO 3 (mmol/l)

28.2 [27.0, 28.6]

27.3 [26.9, 27.8]

29.8 [27.8, 30.2]θ

Lactate (mmol/l)

1.0 [0.6, 1.2]

1.0 [0.6, 1.1]

0.9 [0.7, 1.0]

  1. Values are Median [interquartile range]. Abbreviations: ALT, alanine transaminase; AP, alkaline phosphatase; AST, aspartate transaminase; HCO3, bicarbonate; INR, international normalized ratio; LDH, lactate dehydrogenase; MCV, mean corpuscular volume; pCO2, partial pressure of carbon dioxide; pO2, partial pressure of oxygen.
  2. #1 rat in the CCl4-1xWk group and 2 in the CCl4-2xWk group had no laboratory data.
  3. *p < 0.05 vs. Control, **p < 0.01 vs. Control, ***p < 0.001 vs. Control, ****p < 0.0001 vs. Control, θp < 0.05 vs. CCl4-1xWk, θθp < 0.01 vs. CCl4-1xWk, θθθθp < 0.0001 vs. CCl4-1xWk.
Back to article page