Figure 6

Effect of 1 mA DCS on bEnd3 permeability to Dextran 70 kDa (A,C) and TAMRA (B,D) under convective (A,B) or diffusive (C,D) conditions. (A) Dextran permeability increased by 2-fold under convective conditions and (C) by 5.5-fold under diffusive conditions (C). There was no increase in TAMRA permeability under either condition (B,D). N = 12 for (A); N = 13 for (B); N = 8 for (C) and (D). *p = 7 × 10−5 in (A) and p = 0.004 in (B) vs baseline by paired t-test.