Figure 2 | Scientific Reports

Figure 2

From: ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells

Figure 2

Donor-specificity of phBEC IL-8 induction following in vitro ozone exposure. We investigated whether phBEC cultures collected from the same donors at different times had reproducible IL-8 expression following ozone exposure. Seven phBEC donors were used with time between collections ranging from 49–453 days. The consistency of ozone response was assessed by comparing the first exposure response (X-axis) with the second exposure response (Y-axis) via linear regression. Dotted lines are drawn at X = 4.2, Y = 4.2, which is the metric by which we differentiated high and low responders. The shaded areas indicate the quadrants the data points would cluster within if cultures were consistent in their response status (high or low) in both collections one and two.

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