Figure 2 | Scientific Reports

Figure 2

From: Stem cell properties of peripheral blood endothelial progenitors are stimulated by soluble CD146 via miR-21: potential use in autologous cell therapy

Figure 2

Soluble CD146 enhances regenerative properties of ECFC from peripheral blood in an animal model of hindlimb ischaemia. Blood perfusion rate was determined by laser-doppler in hindlimb of nude mice with ischaemia. Animals were injected at day 1 with PBS, ECFC from peripheral blood, or ECFC from peripheral blood obtained in the presence of 50 ng/ml sCD146 or ECFC from cord blood. Blood perfusion was determined in the ischaemic hindlimb and expressed as a % of the blood perfusion measured in the contra-lateral limb. Representative pictures of laser-doppler are shown and mean values +/− SE of 8 animals are given. *,**,***P < 0.05, P < 0.01, P < 0.001, experimental vs no cell at each time. #P < 0.05, pbECFC-sCD146vspbECFC.

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