Table 1 Top 10 miRNAs with previously reported development-associated functions.

miR-10a-5p

HD 10 (up)

Liver fibrosis⁶²

miR-122-5p

HD 6-10 (up)

Expressed in developing liver tissue⁶³/Liver-specific miRNA and maintenance of adult-liver phenotype^35,36/Cholesterol and lipid metabolism^36,64

miR-124-3p

HD 3–10 (down)

Cholangiocyte proliferation⁶⁵/Brain-specific miRNA^65,66

miR-146b-5p

HD 10 (up)

Intestinal epithelial cell differentiation⁶⁷/Visceral preadipocyte proliferation and differentiation⁶⁸/Regulator of inflammation in epithelial cells, lung fibroblasts and others⁶⁹

miR-184

HD 10 (up)

—

miR-192-5p/194-3p

HD 6–10 (up)

Liver-abundant miRNAs⁷⁰/Intestinal epithelial cell differentiation⁷¹

miR-489-3p

HD 3 (enriched)

Increased in all germ layers, highest in the endoderm¹¹

miR-517a-3p/-526b-5p

HD 3–10 (down)

Members of C19MC cluster, which is involved in pluripotent stem cell status^72,73

miR-10a-5p

KD 6 (enriched)

Biomarkers of kidney injury⁷⁴

miR-10b-5p

KD 6 (enriched)

—

miR-181a-5p

KD 10 (up)

Expressed in kidney tissue⁷⁵/Hematopoietic lineage differentiation⁷⁵

miR-214–3p

KD 10 (up)

Differentiation of ESCs into endothelial cells⁷⁶/Osteogenic differentiation⁷⁷

miR-302a-5p/3p/-302c-5p/-302d-5p

KD 10 (down)

hPSC-specific miRNAs²²/Definitive endoderm formation¹²

miR-371a-3p

KD 10 (down)

hPSC-specific miRNAs²²/Mesendoderm specification⁷⁸

let-7e-5p

KD 10 (up)

Early nephrogenic differentiation³⁸

miR-10a-5p

ND 10 (up)

Neuron differentiation⁷⁹

miR-181a-2-3p

ND 3 (down)

Regulation of synaptic functions⁸⁰

miR-1208

ND 6 (enriched)

—

miR-375

ND 6–10 (up)

Inhibition of neurite differentiation⁸¹/Spinal motor neuron development⁸²

miR-4470

ND 3–6 (up)

—

miR-520a-5p/-520g-3p/-526b-5p

ND 3–10 (down)

Members of C19MC cluster, which is involved in pluripotent stem cell status^72,73

miR-664b-5p

ND 3–10 (up)

—

miR-934

ND 6–10 (up)

—