Figure 6

Damage of tumour blood vessels and tumours in dorsal window chamber after CaEP or ECT with bleomycin (BLM). Bright-field images of tumours and blood vessels in dorsal window chamber before the therapy (Day 0) and fluorescence images of tumours (green) and blood vessels (red) on day 1 and 3 after the therapy. Graphs demonstrate fluorescence area of representative tumours indicating tumour growth normalized to day 0 (control – black line; treated tumour – red line). For each group, two to three mice were randomly assigned. Due to high melanin content and fast tumour growth, control tumours were monitored for only 3 days. Only best-responding tumours treated with combined therapy were monitored for up to 7 days (data not shown).