Figure 1
Structure of the MVM capsid and distribution of capsid-bound DNA segments and electrically charged residues at the capsid inner wall. (a) Scheme of the icosahedral MVM capsid architecture. Trimeric CBBs are idealized as triangles and the interfaces between the three capsid subunits in one trimer (center) are idealized as straight lines. S5, S3 and S2 symmetry axes are indicated. (b) Cross-section of the atomic structure of the MVM virion51,52. Structurally equivalent ssDNA segments bound to equivalent sites at the capsid inner wall are colored yellow. Residues R54, Q137 and Q255 close to the capsid-bound DNA segments are colored red, and those surrounding one DNA segment are labelled. (c) Distribution of electrically charged residues at the structured inner wall of the MVMp capsid52. For clarity, only a pentamer of trimers around a S5 axis (15 VP2 subunits, one fourth of the capsid) is represented, as seen from the capsid interior. Basic or acidic residues are respectively coloured blue or red. Residues E146, D263, E264 of five capsid subunits (labelled for one subunit) define a conspicuous ring of 15 negatively charged carboxylates that surrounds each capsid pore (center).
