Table 4 Comparison of the models’ predicated percentage of dose subgroup

From: Warfarin maintenance dose Prediction for Patients undergoing heart valve replacement— a hybrid model with genetic algorithm and Back-Propagation neural network

Model

Low dose subgroup < = 2.5 mg/d

Intermediate dose subgroup 2.5~3.0 mg/d

High dose subgroup > = 3.0 mg/d

Underestimate (%)

Ideal (%)

Overestimate (%)

Underestimate (%)

Ideal** (%)

Overestimate (%)

Underestimate (%)

Ideal (%)

Overestimate (%)

BP-GA iv

0 (0.0)

1 (0.2)

464 (99.8)

334 (12.4)

2085 (77.9)

259 (9.7)

412 (99.3)

2 (0.5)

1 (0.2)

BP-GA ev

0 (0.0)

0 (0.0)

198 (100)

85 (7.8)

920 (84.2)

88 (8.1)

172 (100)

0 (0.0)

0 (0.0)

  1. Note: BP-GA iv: the internal validation group; BP-GA ev: the external validation group.
  2. **P < 0.05 (chi-square test the ideal percentage between the internal and external validation group).
  3. Ideal: the percentage of patients whose predicted absolute error between predicted dose and actual dose was within 20% of actual dose.
  4. Underestimate: the percentage of patients whose predicted dose was less than actual dose and the predicted absolute error between predicted dose and actual dose was more than 20% of the actual dose.
  5. Overestimate: the percentage of patients whose predicted dose was more than actual dose and the predicted absolute error between predicted dose and actual dose was more than 20% of the actual dose.
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