Table 2 Genotype and allele distributions of IFIH1 gene polymorphisms and associations with SLE.
SNPs | Model | Genotype | SLE | Controls | OR (95%CI) | P- value | ||
|---|---|---|---|---|---|---|---|---|
(n = 400) | (n = 659) | |||||||
N | Frequency | N | Frequency | |||||
rs1990760 C > T | CC | 236 | 59.00% | 447 | 67.83% | 1 | — | |
CT | 147 | 36.75% | 191 | 28.98% | 1.46 (1.12–1.90) | 0.006 | ||
TT | 17 | 4.25% | 21 | 3.19% | 1.53 (0.79–2.96) | 0.200 | ||
Dominant | TT + CT/CC | — | 69.49% | — | 47.43% | 1.47 (1.13–1.90) | 0.004 | |
Recessive | TT/CT + CC | — | 4.44% | — | 3.29% | 1.35 (0.70–2.59) | 0.367 | |
Allelic | C | 619 | 77.38% | 1085 | 82.32% | 1 | — | |
T | 181 | 22.63% | 233 | 17.68% | 1.36 (1.10–1.69) | 0.005 | ||
rs3747517 T > C | TT | 161 | 40.25% | 331 | 50.23% | 1 | — | |
CT | 193 | 48.25% | 265 | 40.21% | 1.50 (1.15–1.95) | 0.003 | ||
CC | 46 | 11.50% | 63 | 9.56% | 1.50 (0.98–2.29) | 0.060 | ||
Dominant | CC + CT/TT | — | 148.45% | — | 99.09% | 1.50 (1.17–1.93) | 0.002 | |
Recessive | CC/CT + TT | — | 12.99% | — | 10.57% | 1.23 (0.82–1.84) | 0.314 | |
Allelic | T | 515 | 64.38% | 927 | 70.33% | 1 | — | |
C | 285 | 35.63% | 391 | 29.67% | 1.31 (1.09–1.58) | 0.004 | ||
rs10930046 T > C | TT | 298 | 74.50% | 512 | 77.69% | 1 | — | |
CT | 98 | 24.50% | 140 | 21.24% | 1.20 (0.90–1.62) | 0.220 | ||
CC | 4 | 1.00% | 7 | 1.06% | 0.98 (0.29–3.38) | 0.977 | ||
Dominant | CC + CT/TT | — | 34.23% | — | 28.71% | 1.19 (0.89–1.59) | 0.235 | |
Recessive | CC/CT + TT | — | 1.01% | — | 1.07% | 0.94 (0.27–3.23) | 0.923 | |
Allelic | T | 694 | 86.75% | 1164 | 88.32% | 1 | — | |
C | 106 | 13.25% | 154 | 11.68% | 1.15 (0.89–1.50) | 0.287 | ||
