Table 2 Associations of rs11177 and rs6617 with a KOA risk.
Group | H-WE P-value | Allele number (%) | Allelic P-value* | OR* 95% CI | Genotype number (%) | Genotypic P-value* | ||||
|---|---|---|---|---|---|---|---|---|---|---|
The discovery stage | ||||||||||
rs11177 | G | A | GG | GA | AA | Co-dominant model | 0.000021 | |||
Case | 0.712 | 1056(50.19) | 1048(49.81) | 0.000026 | 1.25 | 268(25.48) | 520(49.43) | 264(25.1) | Dominant model | 0.001573 |
Control | 0.670 | 2362(55.79) | 1872(44.21) | 1.13–1.39 | 654(30.89) | 1054(49.79) | 409(19.32) | Recessive model | 0.000182 | |
The replication stage | ||||||||||
rs11177 | G | A | GG | GA | AA | Co-dominant model | 0.000014 | |||
0.663 | 1181(50.34) | 1165(49.66) | 0.000011 | 1.25 | 301(25.66) | 579(49.36) | 293(24.98) | Dominant model | 0.000552 | |
0.912 | 2640(55.88) | 2084(44.12) | 1.13–1.38 | 739(31.29) | 1162(49.2) | 461(19.52) | Recessive model | 0.000193 | ||
rs6617 | C | G | CC | CG | GG | Co-dominant model | 0.000834 | |||
0.335 | 1177(50.17) | 1169(49.83) | 0.000222 | 1.21 | 287(24.47) | 603(51.41) | 283(24.13) | Dominant model | 0.000552 | |
0.934 | 2590(54.83) | 2134(45.17) | 1.09–1.33 | 709(30.02) | 1172(49.62) | 481(20.36) | Recessive model | 0.010504 | ||
