Table 2 Summary table with pathways, number of genes and their direction.
Days of exposure | Group of pathways | Pathways | q-value | pathway source | Down | Up | Total |
|---|---|---|---|---|---|---|---|
2 days | Signal transduction | Olfactory transduction | 5.10E-12 | KEGG | 5 | 26 | 31 |
Olfactory signalling Pathway | 4.61E-05 | Reactome | 5 | 10 | 15 | ||
GPCR downstream signalling | 0.0183 | Reactome | 8 | 13 | 21 | ||
Signalling by GPCR | 0.0347 | Reactome | 8 | 14 | 22 | ||
7 days | Signal transduction | Class A/1 (Rhodopsin-like receptors) | 2.42E-03 | Reactome | 45 | 21 | 66 |
GPCR ligand binding | 3.86E-03 | Reactome | 56 | 23 | 79 | ||
Peptide ligand-binding receptors | 1.56E-02 | Reactome | 28 | 14 | 42 | ||
G alpha (s) signalling events | 1.63E-02 | Reactome | 18 | 9 | 27 | ||
Non-odorant GPCRs | 3.06E-02 | Wikipathways | 36 | 19 | 55 | ||
Antagonism of Activin by Follistatin | 2.42E-02 | Reactome | 4 | 0 | 4 | ||
Xenobiotics metabolism | Phase 1 - Functionalization of compounds | 6.41E-04 | Reactome | 6 | 24 | 30 | |
Biological oxidations | 8.93E-05 | Reactome | 8 | 39 | 47 | ||
Xenobiotics | 7.40E-04 | Reactome | 1 | 15 | 16 | ||
Cytochrome P450 - arranged by substrate type | 5.75E-03 | Reactome | 3 | 20 | 23 | ||
bupropion degradation | 5.75E-03 | MouseCyc | 1 | 13 | 14 | ||
nicotine degradation III | 7.23E-03 | MouseCyc | 1 | 14 | 15 | ||
Metabolism of xenobiotics by cytochrome P450 | 7.54E-03 | KEGG | 3 | 23 | 26 | ||
Drug metabolism - cytochrome P450 | 8.75E-03 | KEGG | 2 | 23 | 25 | ||
nicotine degradation II | 9.60E-03 | MouseCyc | 2 | 14 | 16 | ||
Drug metabolism - other enzymes | 2.31E-02 | KEGG | 1 | 16 | 17 | ||
Metabolism | Nuclear receptors in lipid metabolism and toxicity | 1.04E-02 | Wikipathways | 4 | 9 | 13 | |
Prostaglandin Synthesis and Regulation | 2.42E-02 | Wikipathways | 10 | 3 | 13 | ||
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 8.37E-03 | Reactome | 0 | 10 | 10 | ||
Synthesis of (16–20)-hydroxyeicosatetraenoic acids (HETE) | 3.67E-02 | Reactome | 0 | 10 | 10 | ||
Ascorbate and aldarate metabolism | 2.53E-02 | KEGG | 0 | 9 | 9 | ||
Linoleic acid metabolism | 2.24E-02 | KEGG | 2 | 14 | 16 | ||
Arachidonic acid metabolism | 6.41E-04 | Reactome | 18 | 23 | 41 | ||
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 1.83E-02 | Reactome | 5 | 5 | 10 | ||
Propanoate metabolism | 4.98E-02 | KEGG | 1 | 11 | 12 | ||
UDP-N-acetyl-D-glucosamine biosynthesis II | 2.33E-02 | MouseCyc | 1 | 4 | 5 | ||
Metabolism of proteins | Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 3.86E-03 | Reactome | 5 | 9 | 14 | |
O-linked glycosylation of mucins | 9.60E-03 | Reactome | 3 | 13 | 16 | ||
Mucin type O-Glycan biosynthesis | 1.63E-03 | KEGG | 4 | 10 | 14 | ||
Immune response | Cytokine-cytokine receptor interaction | 5.56E-04 | KEGG | 54 | 13 | 67 | |
Complement and coagulation cascades | 9.60E-03 | KEGG | 18 | 3 | 21 | ||
Staphylococcus aureus infection | 4.98E-02 | KEGG | 17 | 0 | 17 | ||
Cancer signalling | Chemical carcinogenesis | 9.60E-03 | KEGG | 3 | 22 | 25 | |
FGFR3c ligand binding and activation | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
FGFR3 ligand binding and activation | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
Signalling by activated point mutants of FGFR3 | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
Signalling by FGFR3 mutants | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
FGFR1c ligand binding and activation | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
Signalling by activated point mutants of FGFR1 | 4.98E-02 | Reactome | 2 | 3 | 5 | ||
Haemostasis | Common Pathway of Fibrin Clot Formation | 4.13E-02 | Reactome | 6 | 1 | 7 | |
Cell surface interactions at the vascular wall | 2.26E-02 | Reactome | 18 | 8 | 26 | ||
Extracellular matrix organisation | Extracellular matrix organization | 1.84E-07 | Reactome | 67 | 8 | 75 | |
Degradation of the extracellular matrix | 3.98E-05 | Reactome | 26 | 5 | 31 | ||
Activation of Matrix Metalloproteinases | 8.93E-05 | Reactome | 17 | 0 | 17 | ||
Matrix Metalloproteinases | 3.86E-03 | Wikipathways | 12 | 1 | 13 | ||
Elastic fibre formation | 2.42E-02 | Reactome | 12 | 1 | 13 | ||
Collagen formation | 3.69E-02 | Reactome | 21 | 1 | 22 | ||
Assembly of collagen fibrils and other multimeric structures | 3.83E-02 | Reactome | 11 | 1 | 12 | ||
Digestive system | Bile secretion | 1.36E-03 | KEGG | 6 | 20 | 26 | |
Pancreatic secretion | 8.76E-03 | KEGG | 15 | 16 | 31 | ||
Amino sugar and nucleotide sugar metabolism | 1.03E-02 | KEGG | 3 | 16 | 19 | ||
Protein digestion and absorption | 9.60E-03 | KEGG | 16 | 12 | 28 | ||
Mineral absorption | 6.41E-04 | KEGG | 8 | 13 | 21 | ||
7 days | Endocrine and metabolic disease | Maturity onset diabetes of the young | 3.86E-03 | KEGG | 0 | 13 | 13 |
Muscle contraction | Striated Muscle Contraction | 4.07E-04 | Reactome | 15 | 1 | 16 | |
Muscle contraction | 4.29E-02 | Reactome | 15 | 2 | 17 | ||
Bone development | Endochondral Ossification | 9.68E-04 | Wikipathways | 20 | 5 | 25 | |
Endocrine and other factor-regulated calcium reabsorption | 2.17E-02 | KEGG | 5 | 14 | 19 | ||
Calcium signalling pathway | 2.33E-02 | KEGG | 26 | 20 | 46 | ||
Transport of molecules | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | 8.76E-03 | Reactome | 12 | 17 | 29 | |
Ion channel transport | 2.11E-02 | Reactome | 12 | 23 | 35 | ||
Ion transport by P-type ATPases | 2.26E-02 | Reactome | 7 | 7 | 14 | ||
Organic cation transport | 4.98E-02 | Reactome | 1 | 4 | 5 | ||
Transmembrane transport of small molecules | 7.00E-03 | Reactome | 41 | 69 | 110 | ||
14 days | Signal transduction | Olfactory transduction | 1.57E-44 | KEGG | 77 | 72 | 149 |
GPCR downstream signalling | 5.28E-26 | Reactome | 97 | 60 | 157 | ||
Signalling by GPCR | 8.59E-25 | Reactome | 106 | 63 | 169 | ||
Olfactory signalling Pathway | 6.18E-24 | Reactome | 43 | 36 | 79 | ||
Signal Transduction | 2.50E-10 | Reactome | 143 | 82 | 225 | ||
Odorant GPCRs | 2.51E-09 | Wikipathways | 24 | 19 | 43 | ||
GPCR ligand binding | 5.85E-07 | Reactome | 44 | 23 | 67 | ||
GPCRs, Class A Rhodopsin-like | 1.51E-06 | Wikipathways | 23 | 19 | 42 | ||
GPCRs, Other | 1.80E-06 | Wikipathways | 18 | 12 | 30 | ||
Non-odorant GPCRs | 3.08E-06 | Wikipathways | 34 | 17 | 51 | ||
Class A/1 (Rhodopsin-like receptors) | 4.40E-04 | Reactome | 32 | 16 | 48 | ||
G alpha (i) signalling events | 4.05E-03 | Reactome | 24 | 11 | 35 | ||
Taste transduction | 9.95E-03 | KEGG | 8 | 4 | 12 | ||
Monoamine GPCRs | 2.96E-02 | Wikipathways | 4 | 5 | 9 | ||
G alpha (s) signalling events | 3.12E-02 | Reactome | 13 | 6 | 19 | ||
G alpha (q) signalling events | 4.20E-02 | Reactome | 18 | 9 | 27 | ||
Class C/3 (Metabotropic glutamate/pheromone receptors) | 4.05E-03 | Reactome | 5 | 4 | 9 | ||
Amine ligand-binding receptors | 3.45E-02 | Reactome | 5 | 3 | 8 | ||
Xenobiotics metabolism | Phase 1 - Functionalization of compounds | 1.60E-02 | Reactome | 3 | 16 | 19 | |
Biological oxidations | 6.38E-03 | Reactome | 4 | 25 | 29 | ||
Drug metabolism - other enzymes | 2.43E-02 | KEGG | 2 | 11 | 13 | ||
Drug metabolism - cytochrome P450 | 3.12E-02 | KEGG | 3 | 14 | 17 | ||
Cytochrome P450 - arranged by substrate type | 3.82E-02 | Reactome | 1 | 14 | 15 | ||
Metabolism | Steroid hormone biosynthesis | 6.38E-03 | KEGG | 4 | 4 | 8 | |
Steroid hormones | 2.73E-02 | Reactome | 3 | 10 | 13 | ||
Retinol metabolism | 1.08E-04 | KEGG | 2 | 18 | 20 | ||
Ascorbate and aldarate metabolism | 1.72E-03 | KEGG | 2 | 7 | 9 | ||
Vitamin D (calciferol) metabolism | 6.67E-03 | Reactome | 1 | 3 | 4 | ||
Metabolism of steroid hormones and vitamin D | 2.73E-02 | Reactome | 4 | 4 | 8 | ||
Cancer signalling | Chemical carcinogenesis | 1.78E-02 | KEGG | 4 | 14 | 18 | |
Digestive system | Recycling of bile acids and salts | 4.98E-03 | Reactome | 2 | 5 | 7 | |
Fatty acid degradation | 1.98E-02 | KEGG | 1 | 12 | 13 | ||
Linoleic acid metabolism | 2.96E-02 | KEGG | 3 | 9 | 11 | ||
Bile secretion | 3.45E-02 | KEGG | 3 | 13 | 16 | ||
Fatty acids | 3.86E-02 | Reactome | 0 | 6 | 6 | ||
Transport of molecules | Transmembrane transport of small molecules | 4.20E-03 | Reactome | 35 | 41 | 76 | |
SLC-mediated transmembrane transport | 3.12E-02 | Reactome | 15 | 26 | 41 | ||
Transport of vitamins, nucleosides, and related molecules | 3.45E-02 | Reactome | 4 | 6 | 10 | ||
Neuronal response | Neuroactive ligand-receptor interaction | 4.55E-06 | KEGG | 28 | 24 | 52 | |
Serotonin receptors | 4.37E-02 | Reactome | 3 | 1 | 4 | ||
21 days | Signal transduction | Olfactory transduction | 3.02E-02 | KEGG | 29 | 5 | 34 |
G Protein signalling Pathways | 4.31E-02 | Wikipathways | 13 | 0 | 13 | ||
Immune response | Cell adhesion molecules (CAMs) | 8.19E-04 | KEGG | 22 | 0 | 22 | |
Innate Immune System | 4.75E-03 | Reactome | 41 | 0 | 41 | ||
Immune System | 5.76E-03 | Reactome | 63 | 0 | 63 | ||
Extracellular matrix | Extracellular matrix organization | 1.51E-02 | Reactome | 23 | 0 | 23 | |
Regulation of actin cytoskeleton | 3.53E-02 | KEGG | 21 | 0 | 21 | ||
Neuronal response | Neuronal System | 5.76E-03 | Reactome | 24 | 1 | 25 | |
Transmission across Chemical Synapses | 1.50E-02 | Reactome | 18 | 1 | 19 | ||
Serotonin and anxiety-related events | 2.73E-02 | Wikipathways | 4 | 0 | 4 | ||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | 4.31E-02 | Reactome | 14 | 0 | 14 | ||
HCN channels | 3.02E-02 | Reactome | 3 | 0 | 3 |
