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Figure 1

From: Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction

Figure 1

GzmB levels are elevated in the DEJ of sub-epidermal blistering diseases. (a) In the upper row, representative images of H&E staining of healthy skin, bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA). Dotted lines delineate blisters. In the lower row, GzmB immunostaining of healthy, bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA) biopsies. Abundant GzmB is observed at the level of the dermal-epidermal junction in diseased skin particularly in areas of epidermal separation (black arrowheads). Dotted lines indicate separation between the epidermis and the dermis. Scale bars represent 200 μm. (b) In the upper row, representative images of H&E staining of, bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA). In lower row, GzmB staining for the same tissue sections. In all conditions studied GzmB co-localizes with neutrophils (red circles). Scale bars represent 40 μm.

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