Table 1 Basic characteristics of HCC patients stratified according to the 5-HT level and YAP/VGLL4 balance.
Variable | Overall | 5-HT | YAP/VGLL4 ratio | ||||
|---|---|---|---|---|---|---|---|
Lower (n = 62) | Higher (n = 62) | P | Lower (n = 47) | Higher (m = 77) | P | ||
Sex, male/female | 98/26 | 51/11 | 47/15 | 0.379 | 36/11 | 62/15 | 0.604 |
Age (ys) | 51.1 ± 9.8 | 51.4 ± 9.5 | 50.8 ± 10.0 | 0.742 | 51.2 ± 11.3 | 51.1 ± 8.8 | 0.948 |
ALT (U/L) | 47.5 (11–492) | 44 (11–359) | 52 (13–492) | 0.615 | 41 (11–492) | 53 (13–433) | 0.460 |
AST (U/L) | 46 (13–561) | 41 (13–356) | 53 (17–561) | 0.119 | 40 (13–561) | 48 (17–330) | 0.070 |
ALP (U/L) | 97 (26–388) | 92 (26–241) | 105 (56–388) | 0.178 | 88 (36–173) | 110 (26–388) | 0.010 |
GGT (U/L) | 69.5 (13–803) | 59 (13–381) | 83 (14–803) | 0.235 | 44 (15–274) | 90 (13–803) | <0.001 |
PLT (109/L) | 124 (25–417) | 100 (25–227) | 145 (32–417) | <0.001 | 112 (51–417) | 132 (25–351) | 0.476 |
INR (U/L) | 1.1 (0.8–1.6) | 1.1 (0.8–1.6) | 1.1 (0.8–1.6) | 0.161 | 1.1 (0.8–1.4) | 1.1 (0.8–1.6) | 0.327 |
ALB | 39 (19–52) | 38 (19–52) | 39 (28–51) | 0.503 | 39 (19–52) | 39 (24–51) | 0.513 |
AFP: ≥200/<200 | 62/55 | 26/32 | 36/23 | 0.079 | 19/25 | 43/30 | 0.099 |
Ascites: yes/no | 14/110 | 5/57 | 9/53 | 0.256 | 3/44 | 11/66 | 0.177 |
Cirrhosis: yes/no | 51/73 | 29/33 | 22/40 | 0.201 | 20/27 | 31/46 | 0.801 |
Tumor size: ≥5/<5 cm | 56/68 | 16/46 | 40/22 | <0.001 | 6/41 | 50/27 | <0.001 |
Tumor number: multiple/single | 30/94 | 14/48 | 16/46 | 0.675 | 7/40 | 23/54 | 0.059 |
Child-Pugh: A/B + C | 111/13 | 57/5 | 54/8 | 0.379 | 44/3 | 67/10 | 0.244 |
Vascular invasion: yes/no | 16/108 | 4/58 | 12/50 | 0.032 | 0/47 | 16/61 | 0.001 |
Death: yes/no | 40/84 | 12/52 | 28/34 | 0.002 | 6/41 | 34/43 | <0.001 |
YAP/VGLL4 ratio: high/low | 77/47 | 32/30 | 45/17 | 0.016 | |||
5-HT: high/low | 62/62 | 17/30 | 45/32 | 0.016 | |||
