Figure 2

Composition of the vaginal microbiota during menses as determined by 16S rRNA gene metabarcoding analysis as a function of vaginal colonization by S. aureus. (A) Between-class analysis was performed at the bacterial genus level. Forty-four samples are from women vaginally colonized by S. aureus (green) and 63 from women not colonized by S. aureus (yellow). The analysis is supported by a Monte Carlo test (p = 0.028). Data include the distribution of bacterial OTU according to their contribution to differentiation of the vaginal microbiota of women carrying or not carrying S. aureus. (B) Heatmap showing the average relative proportion of the 10 bacterial genera most commonly associated with vaginal carriage of S. aureus (left) and 10 bacterial genera most often associated with the absence of S. aureus at the vaginal stage (right) in samples containing (lower line) and not containing S. aureus (upper line). Heatmap unit is a percentage of the average relative proportion of taxa.