Figure 5 | Scientific Reports

Figure 5

From: Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

Figure 5

ANG treatment counteracts cytomix and TNF-SKMC-S-CM impact on primary sorted rat beta-cells proliferation. Rat sorted beta-cells were cultured for 24 h with different concentrations of ANG alone or in the presence of cytomix or of different CM. (A) Rat beta-cell proliferation. BrdU-positive beta-cells in sorted rat beta-cells; n = 14. (B) Beta-cell death. TUNEL-positive beta-cells in sorted rat beta-cells; n = 14. (C) Rat sorted beta-cells insulin secretion: 2.8 mM glucose (open bars), 16.7 mM glucose (closed bars); n = 14. *p < 0.05 for the indicated comparison by ANOVA followed by Bonferroni post hoc test.

Back to article page