Figure 3
From: Age at first birth in women is genetically associated with increased risk of schizophrenia
−log(P) values for the null hypothesis of R2 = 0 based on the linear prediction. Full range of AFB: All available samples with a record of age at first birth were used. AFB < 26 (≥26): Analyses were only focus on samples with AFB < 26 (≥26). PRS-GBLUP: Schizophrenia (SCZ) polygenic risk scores estimated from genomic best linear unbiased prediction were used as an explanatory variable in the model. PRS-score: SCZ polygenic risk scores estimated from genome-wide association study based on available individual genotype data were used as an explanatory variable in the model. PRS-scorePGC: SCZ polygenic risk scores estimated from summary statistics results of full PGC SCZ GWAS study were used as an explanatory variable in the model. Response variables were generated with a polynomial function derived by Mehta et al.17, which describes the relationship between SCZ risk in offspring and maternal age (z = 2.7214 − 0.1105X + 0.0018X2, where X is age at first birth), and used in the model in which the AFB phenotypes were adjusted for age at interview, year of birth, assessment center at which participant consented, genotype batch, and the first 20 principal components.
