Figure 6 | Scientific Reports

Figure 6

From: Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57

Figure 6

Identification of ERp57 ligand-binding cavities. (A) Cavities P1-P5 were detected by FLAPsite on the X-ray structure of the ERp57 complex available from the Protein Data Bank with PDB code 3F8U. ERp57 a, a’, b and b’ domains are indicated. (B) ERp57 cavities Volsurf interaction descriptors. Distributions of the Volsurf interaction descriptors for the cavities of the druggable reference set by Cheng et al.27, and position of P1, P2, P3, P4 and P5 cavities found in ERp57 (colored dots).

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