Figure 4
From: Dependence and Homeostasis of Membrane Impedance on Cell Morphology in Cultured Hippocampal Neurons
Computational modelling of the effect of cell morphology on membrane impedance. (a) Schematic representation of the model. (b) Traces (top) and their magnitude spectra (bottom) of the applied chirp current (left) and the voltage response (right) from the 7 DIV patterned model. Only the first 20 s are shown in the traces. (c) Comparison neuron models with different axon length. Using the patterned neuron model at 7 DIV, axon length was varied within the range of 500–2000 μm. Upper and lower panels show the impedance magnitude and phase profiles, respectively. (d,e) Comparison of patterned (red) and unpatterned (black) neuron models which were constructed to mimic the morphology of biological neurons at (d) 7 DIV and (e) 16 DIV. Upper and lower panels show the impedance magnitude and phase profiles, respectively. (f) Ratio of the membrane impedance at 10 Hz in patterned and unpatterned neurons.
