Figure 2 | Scientific Reports

Figure 2

From: Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer’s disease

Figure 2

The architecture of the mushroom body is preserved in flies expressing Aβ42. Representative confocal images of the MBs from flies co-expressing CD8::GFP and LacZ (UAS-LacZ/+; UAS-CD8::GFP/+; ok107-Gal4/+) or Aβ42 (UAS-Aβ42/+; UAS-CD8::GFP/+; ok107-Gal4/+) in the MB neurons at day 1 (a–d), 5 (e,f) and 15 (g,h) post-eclosion. The morphology of the MBs was analyzed in three-dimensional reconstructions of brains from flies raised at 25 °C (a,c,e,g) and 27 °C (b,d,f,h). Frontal (i) and dorsal (ii) view of the MB lobes and dorsal (iii) and frontal (iv) view of the MB calyxes. No significant defects were found at the macroscopic level. Scale bar 30 μm.

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