Table 2 Associations of CTLA-4 49 G/A With Quantitative Traits in 1280 Glucose-Tolerant East Chinese Individuals.
AA | GA | GG | β | SE | P | adjusted P | |
|---|---|---|---|---|---|---|---|
n (men/women) | 128(45/83) | 568(166/402) | 579(186/393) | ||||
Age (years) | 55.9 ± 9.4 | 56.0 ± 9.5 | 55.6 ± 9.0 | ||||
BMI (kg/m2) | 23.8 ± 5.5 | 23.4 ± 3.0 | 23.3 ± 3.2 | 0.176 | 0.146 | 0.228 | |
Plasma glucose (mmol/l) | |||||||
Fasting | 5.3 ± 0.3 | 5.3 ± 0.3 | 5.3 ± 0.4 | −0 | 0.015 | 0.999 | 0.807 |
30 min post OGTT | 8.6 ± 1.6 | 8.6 ± 1.4 | 8.8 ± 1.5 | −0.12 | 0.062 | 0.092 | 0.055 |
120 min post OGTT | 6.2 ± 0.9 | 6.1 ± 1.0 | 6.2 ± 1.0 | −0.04 | 0.04 | 0.472 | 0.287 |
Serum insulin (mIU/l) | |||||||
Fasting | 9.23(7.33–13.45) | 10.12(7.25–14.00) | 9.72(7.33–13.61) | 0 | 0.01 | 0.806 | 0.967 |
30 min post OGTT | 52.59(38.11–80.91) | 59.70(40.59–95.21) | 56.39(36.53–87.34) | 0 | 0.013 | 0.807 | 0.977 |
120 min post OGTT | 42.23(25.79–71.12) | 39.80(25.04–67.00) | 43.15(28.58–65.87) | −0.01 | 0.013 | 0.701 | 0.473 |
islet function | |||||||
HOMA-β | 107.23(80.42–148.39) | 111.77(80.13–160.77) | 104.97(80.83–154.93) | −0 | 0.011 | 0.958 | 0.953 |
IGI | 13.86(9.10–22.42) | 15.70(9.07–26.87) | 14.54(7.69–23.60) | 0.025 | 0.017 | 0.108 | 0.151 |
BIGTT-AIR | 1864.9(1458.7–2619.9) | 2067.4(1490.8–3041.1) | 1903.1(1427.1–2782.6) | 0.003 | 0.014 | 0.823 | 0.84 |
CIR | 144.77(90.66–217.29) | 161.68(95.22–256.91) | 141.62(85.79–227.11) | 0.015 | 0.015 | 0.287 | 0.33 |
insulin resistance | |||||||
HOMA-IR | 2.18(1.70–3.22) | 2.39(1.70–3.33) | 2.31(1.72–3.27) | 0.001 | 0.01 | 0.771 | 0.951 |
ISIc | 0.072(0.038–0.134) | 0.066(0.041–0.112) | 0.068(0.042–0.109) | 0.007 | 0.014 | 0.905 | 0.603 |
BIGTT-SI | 1.7 ± 0.7 | 1.8 ± 0.7 | 1.8 ± 0.7 | −0.01 | 0.03 | 0.819 | 0.831 |
disposition indexes (DI) | |||||||
DI 1 | 13719(9406–17982) | 14463(10376–19329) | 13312(9764–17872) | 0 | 0.014 | 0.987 | 0.993 |
DI 2 | 62.00(40.69–92.88) | 64.74(41.25–108.93) | 59.79(34.63–102.58) | 0.014 | 0.016 | 0.434 | 0.404 |
