Figure 3
From: The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice
DIZE reduced proinflammatory and profibrotic cytokine gene expression. DIZE treated animals had a significantly reduced expression levels of hepatic proinflammatory genes, monocyte chemoattractant protein-1 (MCP-1) (A) and interleukin-6 (IL-6) (B) and profibrotic cytokine genes, transforming growth factor-β1 (TGF-β1) (C) and connective tissue growth factor (CTGF) (D) in both BDL and Mdr2-KO mice compared to those in saline-treated BDL and Mdr2-KO mice. Treatment with DIZE inhibited gene expression of MCP-1 (E) and IL-6 (F) and NF-kB activity (G) in lipopolysaccharide (LPS)-stimulated Kupffer cells (KUP5 cells). Each bar represents the mean ± SEM profile from 10–15 mice (panels A–D) or 3 independent experiments (panels E–G) per treatment group.
