Figure 7 | Scientific Reports

Figure 7

From: Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection

Figure 7The alternative text for this image may have been generated using AI.

il10e46/e46 mutant zebrafish have an enhanced Th1 cell mediated immune response in a mycobacterial infection. (a–e) The relative expressions of Cd4 + lymphocyte transcription factors (tbx21, gata3, foxp3a) and Th cell cytokines (ifng1 and il4) in kidneys of unchallenged il10e46/e46 mutants (n = 10) and WT control fish (n = 10) and in the unsorted kidney cell populations of il10e46/e46 mutants (n = 10–14) and WT control fish (n = 10–12) at 4 and 8 weeks post a low-dose (1–18 CFU) infection (on the left) as well as in the abdominal organ blocks (including kidney) of unchallenged il10e46/e46 mutants (n = 12) and WT control fish (n = 11–12) and at 4 and 9 weeks post a low-dose (2–9 CFU) infection (n = 12 and n = 12, respectively) (on the right) were measured with qPCR. Data are presented as a scatter dot plot and median. Gene expressions were normalized to the expression of eef1a1l1. Each dataset was collected from a single experiment. A two-tailed Mann-Whitney was used for the statistical comparison of differences.

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