Figure 7
GABBR1 is negatively correlated with AR expression and positively correlated with ENO2 expression in NEPC. (a) GABBR1 and AR expression are negatively correlated at protein level, left panel (r = −0.179; p = 0.03; n = 146) and mRNA level, right panel (r = −0.274; p = 0.003677−4; n = 333). Previously published prostate cancer gene and protein expression data set40 was acquired from cBioPortal51,52. GABBR1 and AR expression values were retrieved and plotted. Previously published RNA-seq of 49 CRPC12 with or without neuroendocrine differentiation was obtained from cBioPortal51,52. (b) GABBR1 and ENO2 mRNA expression are positively correlated in NEPC group (r = 0.539; p = 0.03; n = 15) compared to CRPC group (r = 0.223; p = 0.22; n = 32). (c) The AR, ENO2 and GABBR1 expression values were plotted comparing NEPC to CRPC.
