Table 3 Upregulated gene sets with different adjustment models for covariates.

From: Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study

Gene set name

FL (n = 316)

NAFL (n = 223)

AFL (n = 55)

M1

M2

M1

M2

M1

M2

ECM turnover

  INTEGRIN_A4B1_PATHWAY

<0.001

0.013

<0.001

0.012

0.820

NA

  INTEGRIN_CELL_SURFACE_INTERACTIONS

<0.001

0.289

<0.001

0.768

0.025

0.102

  ECM_RECEPTOR_INTERACTION

<0.001

0.370

0.002

NA

0.132

0.674

  MCALPAIN_PATHWAY

<0.001

0.076

0.004

0.089

0.168

0.542

Immune response regulation

  CD40_PATHWAY

<0.001

<0.001

<0.001

<0.001

0.075

0.376

  LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

<0.001

0.023

0.016

0.092

0.203

0.369

  SIGNALLING_TO_ERKS

<0.001

0.054

0.002

0.082

0.088

0.271

  HIVNEF_PATHWAY

0.002

0.080

0.004

0.215

0.042

0.191

Thrombosis

  INTEGRIN_ALPHAIIB_BETA3_SIGNALING

<0.001

0.227

0.006

0.926

<0.001

0.119

  PLATELET_AGGREGATION_PLUG_FORMATION

<0.001

0.185

0.004

0.898

<0.001

0.139

  UPA_UPAR_PATHWAY

0.004

0.107

0.006

0.098

0.017

0.307

Neural tissue

  NETRIN1_SIGNALING

<0.001

0.018

<0.001

0.012

0.202

NA

  AGR_PATHWAY

<0.001

0.110

<0.001

0.133

0.336

NA

  ALPHA_SYNUCLEIN_PATHWAY

0.004

0.479

<0.001

0.393

0.242

0.959

  1. Values are shown as nominal p values for each gene set in the specified groups compared to normal liver group (n = 1334).
  2. Statistics: Model 1 (M1) is adjusted for age, sex and 20 principal components; Model 2 (M2) is adjusted for age, sex, 20 principal components, body mass index, apolipoprotein B, triglycerides, insulin, systolic blood pressure, ALT, alcohol consumption and physical activity index. FL, Fatty liver; NAFL, non-alcoholic fatty liver; AFL, alcoholic fatty liver. NA means that the pathway was not upregulated in the specific group.
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