Figure 4

Method of ROI selection. Three background ROIs were drawn according to the traditional method in (a). The average counts per pixel for ROI-1, ROI-2, and ROI-3 are 18.143, 21.714 and 30.500, respectively. Distinct differences could be noticed and these differences would result in inaccuracy for radioactive activity quantification. In (b) the ROI-1 in blue colour represents the target tissue (rat thyroid) defined according to the UC-ROI drawing method. The ROI-2 in yellow colour, which is drawn in a narrow circle shape next to ROI-1, represents the background region.