Table 2 Univariate and multivariate analyses of factors affecting the incidence of grade II–IV acute graft- versus-host disease after allogeneic hematopoietic stem cell transplantation at neutrophil engraftment.

From: Soluble interleukin-27 receptor alpha is a valuable prognostic biomarker for acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

Factor

Univariate analysis

Multivariate analysis

Incidence of acute GVHD (%)

P value

Hazard ratio

95% CI

P value

Patient age (years)

  <50

39.1

0.94

   

  ≥50

40.0

    

Gender

  Male

40.0

0.11

   

  Female

51.9

    

GVHD prophylaxis

     

  FK506

45.0

0.57

   

  CSA

36.7

    

Donor age

  <35

27.8

0.04

1

1.11–4.82

0.03

  ≥35

51.5

 

2.31

  

sIL-27Rα level

  <59.40

65.2

<0.01

2.83

1.29–6.19

<0.01

  ≥59.40

26.1

 

1

  

Disease status

  High risk

54.5

0.08

1.42

0.69–2.97

0.34

  Standard risk

31.9

 

1

  

Patient-donor sex

  match

38.6

0.81

   

  mismatch

40.0

    

Donor type

  Unrelated

42.9

0.98

   

  Related

37.5

    
  1. Note: 3 patients were excluded because they developed grade II–IV aGVHD before neutrophil engraftment.
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