Table 1 Experimental and predicted values of response variables for Box-behnken design.

From: Enhanced physicochemical stability and efficacy of angiotensin I-converting enzyme (ACE) - inhibitory biopeptides by chitosan nanoparticles optimized using Box-Behnken design

Run order

aIndependent variables

bDependent variables

A

B

C

R1 (Mean particle size, nm)

R2 (Encapsulation efficiency, %)

Predicted

Experimental

Predicted

Experimenta

1

0.35

8000

30

163.755

164.90

73.3484

73.92

2

0.50

7000

20

210.328

210.78

50.4725

49.93

3

0.35

6000

20

215.238

213.87

51.7059

50.70

4

0.20

6000

25

208.456

209.63

67.8563

69.23

5

0.20

7000

30

190.645

189.97

72.6800

71.66

6

0.20

8000

25

169.409

168.97

75.8688

76.10

7

0.20

7000

20

196.000

195.94

71.0450

70.46

8

0.35

7000

25

191.362

190.00

66.3271

65.61

9

0.50

6000

25

215.704

216.65

46.7288

48.06

10

0.35

8000

20

171.140

171.67

73.5934

73.73

11

0.35

7000

25

191.362

190.94

66.3271

65.62

12

0.35

7000

25

191.362

193.59

66.3271

68.62

13

0.50

8000

25

176.656

175.42

67.2912

67.48

14

0.35

6000

30

197.753

197.00

66.6609

66.09

15

0.50

7000

30

190.813

190.65

63.5475

62.57

  1. aIndependent variables for encapsulation of SBs: A; SBs:Chitosan mass ratio, B; homogenization speed (rmp), C; homogenization time (min).
  2. bDependent variables: R1; mean particle size (nm); R2; encapsulation efficiency (%).
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