Figure 1 | Scientific Reports

Figure 1

From: A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

Figure 1

The SK channels IDF connects the CaMBD and transmembrane domain S6. (a) A simplified gating scheme for Ca2+-dependent SK channel activation may include two steps: (1) binding of Ca2+ to CaM associated with the SK channel and (2) mechanical coupling between Ca2+ binding to CaM and subsequent channel opening. (b) Amino acid sequence alignment of mammalian SK channels at the region connecting the CaMBD and the S6 transmembrane domain. Seven amino acid residues from the IDF shown in magenta are the focus of this study. Human and rat sequences are identical at this region. (c) Seven residues from the IDF (in magenta) are located between the CaMBD and the transmembrane S6 domain.

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