Figure 2

Mutations in the IDF change SK2-a channel Ca²⁺ sensitivity. (a) Dose-dependent activation by Ca²⁺ of the WT and alanine mutant SK2-a channels. (b) EC₅₀ values for activation by Ca²⁺ of the WT and alanine mutant channels. (c) Dose-dependent activation by Ca²⁺ of the WT and phenylalanine mutant SK2-a channels. (d) EC₅₀ values for activation by Ca²⁺ of the WT and phenylalanine mutant channels. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc tests. All data are presented as mean ± s.e.m.