Figure 4

Sensory transduction in Rosa26^tm(CAG-LSL-Tmc2-IRES-GFP);Tmc1^Δ/Δ mice. (A,B) Sensory transduction currents were recorded from P1-9 GFP-positive and GFP-negative OHCs of Rosa26^tm(CAG-LSL-Tmc2-IRES-GFP);Gfi1^Cre/+;Tmc1^Δ/Δ mice. While absent in GFP-negative P1-P2 OHCs, large currents were recorded in P1-P2 GFP-positive cells. (C–E) Currents were recorded from P1-P25 GFP-positive and P1-P18 GFP-negative IHCs. While currents decreased rapidly in amplitude after P6, large currents were measured GFP-positive cells as late as P25. Number of cells is indicated above the bar graphs. Mean ± S.E.M. ***p < 0.001; **p < 0.01; NS p > 0.05 (one way ANOVA). N/A, non-applicable: GFP-negative IHCs were absent at older stages.