Figure 5
Sensory transduction in Rosa26tm(CAG-LSL-Tmc2-IRES-GFP)/Tmc1Δ/ΔTmc2Δ/Δ mice. (A,B) Sensory transduction currents were recorded from P7-P12 GFP-positive and GFP-negative OHCs. While absent in GFP-negative OHCs at all stages recorded, large currents were recorded in P7-P12 GFP-positive cells. (C,D) Currents were recorded from P7-P37 GFP- positive and P7-P22 GFP-negative IHCs. Large currents were measured in P7 GFP-positive cells. Currents were maintained albeit reduced after P15. In comparison, sensory transduction currents were larger and stable in IHCs of wild type mice at P14 and P20. Number of cells is indicated. Mean ± S.E.M. ***p < 0.001 (one way ANOVA).
