Figure 3
From: Senescent tumor cells building three-dimensional tumor clusters
Confocal immuno-stained image of MDA-MB-231 cells, highlighting cell-rounding. The insets (a,b) are two examples of a cell undergoing mitotic cell-rounding during which the level of E-cadherin expression is diminished significantly, as compared to that of normal cells (for examples, c and d). The level of E-cadherin expression for the huge senescent cells, which barely moves, is also high near the nuclei. Distribution of filamentous actin marker, phalloidin (green), E-cadherin marker (red) and nuclei marker, Hoechst (blue), is shown.
