Figure 4
From: Senescent tumor cells building three-dimensional tumor clusters
Migration pattern of MDA-MB-231 daughter cells on the body of a senescent cell. (a) The sequence of snapshot images shows cells undergoing cell-rounding, all of which are newly replicated daughter cells, migrating towards the senescent core (mean radial velocity: 38.7 μm/hr) (see Supplementary Video S2). (b) A sequence of close-up images showing a process of cell division and, the simultaneous mitotic cell-rounding [square-boxed area in (a)‘s first sequence]. (c) A snapshot image of a senescent cell culminated with a small cell cluster (marked by an arrow) attached onto its core. (scale bar: 100 μm).
