Figure 1
From: A monocyte gene expression signature in the early clinical course of Parkinson’s disease
Comparison of control human monocyte and microglia transcriptomes. (A) Gene expression of selected genes associated with various immune cell types in monocytes isolated from healthy controls revealed by RNA-seq. (B) Gene expression of the 30 most highly expressed genes in human control monocytes from individual control patients. (C) Heat map of mRNA expression values determined in monocytes from 10 controls and in microglia from 19 controls14. 3054 genes exhibited > two-fold higher average expression in monocytes compared to microglia. (D) Gene Ontology enrichment analysis of the top 1000 genes most preferentially expressed in monocytes supports their role as effector cells in immune response. (E) Heat map of mean mRNA expression levels of selected monocyte and microglia genes. RBC - red blood cells; HPC - hematopoietic precursor cells; CD - cluster of differentiation; TPM - transcripts per kilobase million.
