Figure 5

Active site accessibility in three different MLLs. (A) AiiA (PDB: 2A7M) active site cavity appears divided in two parts by two residues (F68 and E135), indicated by pink arrows. (B) AiiB (PDB: 2R2D) active site cavity. AiiB is bound to a phosphate molecule shown as orange sticks. (C) AaL (PDB: 6CGY) active site is bound to a phosphate molecule shown as orange sticks. Active site metal cations are shown as red spheres.