Table 3 Association of pre-diagnostic inflammatory score (A) and the first PC (B) with B-cell non-Hodgkin lymphoma case/control.

From: Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts

 

Full Lymphoma population

TtD ≤ 6 years*

TtD > 6 years*

Model 1

Model 1 + Behaviours

Model 1 + SEP

Fully adjusted model

Fully adjusted model

Fully adjusted model

β (SE)

P-value

β (SE)

P-value

β (SE)

P-value

β (SE)

P-value

β (SE)

P-value

β (SE)

P-value

(A) Inflammatory score

All

−1.28 (0.51)

0.012

−1.19 (0.51)

0.021

−1.21 (0.51)

0.019

−1.11 (0.52)

0.032

−1.27 (0.65)

0.051

−1.06 (0.66)

0.108

EPIC-Italy

−0.89 (0.87)

0.310

−0.93 (0.89)

0.299

−0.96 (0.88)

0.277

−1.02 (0.90)

0.258

−1.87 (1.08)

0.087

0.05 (1.20)

0.965

NSHDS

−1.48 (0.63)

0.019

−1.31 (0.64)

0.040

−1.36 (0.63)

0.031

−1.19 (0.64)

0.062

−0.71 (0.82)

0.389

−1.61 (0.79)

0.043

(B) Principal component 1

All

−0.77 (0.26)

0.004

−0.71 (0.26)

0.007

−0.71 (0.26)

0.007

−0.65 (0.26)

0.013

−0.76 (0.32)

0.018

−0.60 (0.33)

0.073

EPIC-Italy

−0.59 (0.40)

0.138

−0.66 (0.40)

0.101

−0.62 (0.40)

0.126

−0.70 (0.40)

0.083

−1.14 (0.47)

0.017

−0.13 (0.54)

0.816

NSHDS

−0.85 (0.34)

0.012

−0.73 (0.34)

0.032

−0.76 (0.34)

0.024

−0.64 (0.34)

0.059

−0.48 (0.43)

0.263

−0.82 (0.42)

0.053

  1. Pooled cohorts (n = 496), EPIC-Italy (n = 167) and NSHDS (n = 329)
  2. Model 1 is adjusted for age, gender, phase and cohort in the overall all B-cell NHL population; for age, gender, phase and center in EPIC-Italy and age, gender, phase in NSHDS. β coefficient regression estimates inflammatory score’s (A) or PC1’s (B) difference in cases compared to controls.
  3. *Additional analyses stratified by time from blood collection to cases’ diagnosis included for ‘less than 6 years’ strata 129 B-cell NHL cancer cases: 49 in EPIC-Italy and 80 in NSHDS; for ‘higher than 6 years’ strata 119 B-cell NHL cancer cases: 35 in EPIC-Italy and 84 in NSHDS.