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Figure 2

From: Buparlisib is a brain penetrable pan-PI3K inhibitor

Figure 2

The impact of P-gp and BCRP on the brain and tissue penetration of buparlisib. Buparlisib was administered intravenously to wildtype, Abcg2−/−, Abcb1a/b−/− and Abcb1a/b;Abcg2−/− mice at a dose of 2 mg/kg. One hour after injection, blood and tissues were collected for LC-MS/MS analysis. No difference in buparlisib (A) plasma concentration, (B) brain concentration, (C) brain-plasma ratio, (D) liver concentration, (E) kidney concentration and (F) spleen concentration could be observed among the different mouse strains. All data are represented as mean ± SD (n = 4).

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