Figure 5

Some of transferred CD4⁺ T cells convert to TCRαβCD8αα⁺ IELs lineage. (A) Proportion of TCRαβCD8αα⁺ IELs recovered from the small intestine after cell transfer to different hosts. (B) TCRαβCD8αα⁺/TCRαβCD8αβ⁺ T cells ratio in the mesenteric LNs and small intestine epithelium after adoptive transfer of mature CD4⁺ T cells. Scale on Fig. 5B represents ratios of CD8αα/CD8αβ cells in host’s mesenteric lymph nodes (mLN) or small intestine epithelium, which have been derived from injected CD4⁺ lymphocytes. (C) Total numbers of TCRαβ CD4⁺, CD8αβ⁺ and CD8αα⁺ IELs recovered after cell transfer to indicated strains of mice.