Figure 4
From: Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat
iCPT1mt mice and Cpt1mtfl/fl control mice show similar energy intake and whole body energy metabolism when fed CD and when switched to HFD. (A–D) Indirect calorimetry data of Cpt1mtfl/fl and iCPT1mt mice on CD for 48 h and HFD for the next 48 h. The grey and white bars in the background represent the periods of dark and light phases respectively. The dashed lines indicate when the mice were switched from CD to HFD feeding. (A) Respiratory exchange ratio as mean values of 1 h bins. (B) Cumulative energy intake in 1 h bins. (C) Energy expenditure (EE) as mean values of 1 h bins. (D) Locomotor activity as mean values of 1 h bins. (n = 8–11, Mixed RM ANOVA (diet × time × genotype, repeated measures for time and diet for A,B and D; ANCOVA for mean values per day with BW as the covariate for C). (A–D) Data are presented as mean values ± SEM.
