Figure 5
From: Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat
Intestinal CPT1mt expression compromises glycemic control on the CD, but improves it over time on HFD. (A,B) Insulin sensitivity test (IST) for Cpt1mtfl/fl and iCPT1mt mice on CD and HFD, respectively. (A) Left: Tail blood glucose values for CD-fed mice at the time points indicated (n = 10–13). (B) Left: Tail blood glucose values for HFD-fed mice at the time points indicated. Right: Area above the curve (AAC) for the data on the left (n = 16–17). (C-D) Oral glucose tolerance test (OGTT) for Cpt1mtfl/fl and iCPT1mt on CD and HFD respectively. (C) Left: Tail blood glucose values for CD-fed mice at the time points indicated. Right: Area under the curve (AUC) for the data on the left (n = 11–15). (D) Left: Tail blood glucose values for HFD-fed mice at the time points indicated. Right: Area under the curve (AUC) for the data on the left (n = 11–15). (E–F) Intra-peritoneal glucose tolerance test (IPGTT) for Cpt1mtfl/fl and iCPT1mt on CD and HFD respectively. (E) Left: Tail blood glucose values for CD-fed mice at the time points indicated. Right: Area under the curve (AUC) for the data on the left (n = 11–15). (F) Left: Tail blood glucose values for HFD-fed mice at the time points indicated. Right: Area under the curve (AUC) for the data on the left (n = 11–15). (A–F) Mixed RM ANOVA (time x genotype) with repeated measures for time for the line graphs and unpaired t test for the bar graphs. *P < 0.05, **P < 0.05, ***P < 0.001, ****P < 0.0001 for main effect of genotype and simple effects analysis of genotype at each time point in the case of a significant interaction between time and genotype ($). Data are presented as mean values ± SEM.
