Figure 2 | Scientific Reports

Figure 2

From: Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power

Figure 2

Comparisons of allele frequency distributions for different mutation callers. (A) Distribution of Kolmogorov-Smirnov (KS) test p-values corresponding to the null hypothesis that mutation callers will produce similar allele frequency distributions, plotted pairwise for HNSC. The red dashed line indicates the Bonferroni corrected significance threshold \(\alpha =0.05\). The percentage of samples that fall below this threshold are shown on each graph. (B) Percentage of significantly different samples for mutation caller pairs, grouped by cancer type. (C) Comparison of allele frequency distributions using earth mover’s distance.

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